Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria

Cell Envelope Structure and Functions in Gram-negative Bacteria

The CpxAR Two-component System Regulates a Complex Envelope Stress Response in Gram-negative Bacteria

e CpxA membrane bound sensor kinase utilizes a periplasmic sensing domain to detect a wide variety of stresses to the bacterial envelope. !is information is communicated via typical two-component phosphotransfer mediated reactions to the response regulator CpxR. Phosphorylated CpxR binds upstream of numerous promoters to mediate adaptation. Initial studies of CpxA inducing signals and CpxR regu...

Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response

Conditions that impair protein folding in the Gram-negative bacterial envelope cause stress. The destabilizing effects of stress in this compartment are recognized and countered by a number of signal transduction mechanisms. Data presented here reveal another facet of the complex bacterial stress response, release of outer membrane vesicles. Native vesicles are composed of outer membrane and pe...

Antibiotic Resistance Pattern of Gram-Negative Bacteria in Gorgan

Abstract Background and Objective: The excessive use of broad-spectrum antibiotics will lead to drug resistance of microorganism and specially nosocomial organisms. Because of high incidence of antibiotic resistance in hospitals, we aimed to study antibiotic resistance to gram negative bacteria. Material and Methods: This cross-sectional study was conducted on the data of biological sampl...

Regulation and Role of Arabidopsis CUL4-DDB1A-DDB2 in Maintaining Genome Integrity upon UV Stress

Plants use the energy in sunlight for photosynthesis, but as a consequence are exposed to the toxic effect of UV radiation especially on DNA. The UV-induced lesions on DNA affect both transcription and replication and can also have mutagenic consequences. Here we investigated the regulation and the function of the recently described CUL4-DDB1-DDB2 E3 ligase in the maintenance of genome integrit...